{"id":1925,"date":"2021-05-10T06:12:04","date_gmt":"2021-05-10T06:12:04","guid":{"rendered":"http:\/\/3.35.173.53\/?p=1925"},"modified":"2021-05-10T06:12:04","modified_gmt":"2021-05-10T06:12:04","slug":"okereke-o-i-prescott-j-wong-j-y-han-j-rexrode-k-m-de-vivo-i-2012-high-phobic-anxiety-is-related-to-lower-leukocyte-telomere-length-in-women-plos-one-77-e40516","status":"publish","type":"post","link":"https:\/\/www.happyfinder.co.kr\/?p=1925","title":{"rendered":"Okereke, O. I., Prescott, J., Wong, J. Y., Han, J., Rexrode, K. M., &#038; De Vivo, I. (2012). High phobic anxiety is related to lower leukocyte telomere length in women. PloS one, 7(7), e40516."},"content":{"rendered":"<h3>Background<\/h3>\n<p><a name=\"article1.front1.article-meta1.abstract1.sec1.p1\" class=\"link-target\" id=\"article1.front1.article-meta1.abstract1.sec1.p1\"><\/a><\/p>\n<p>Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety \u2013 phobic anxiety \u2013 is related to telomere length.<\/p>\n<div class=\"section toc-section\" id=\"section2\"><a title=\"Methodology\/Principal Findings\" class=\"link-target\"><\/a> <\/p>\n<h3>Methodology\/Principal Findings<\/h3>\n<p><a name=\"article1.front1.article-meta1.abstract1.sec2.p1\" class=\"link-target\" id=\"article1.front1.article-meta1.abstract1.sec2.p1\"><\/a><\/p>\n<p>Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured by quantitative real-time polymerase chain reaction among 5,243 women (aged 42\u201369 years) who: were participants in the Nurses&#8217; Health Study; were controls in prior case-control studies of telomeres and disease, or randomly selected healthy participants in a cognitive function sub-study; had completed the Crown-Crisp phobic index proximal to blood collection. Adjusted least-squares mean RTLs (<em>z<\/em>-scores) were calculated across phobic categories. Higher phobic anxiety was generally associated with lower RTLs (age-adjusted p-trend\u200a=\u200a0.09); this association was similar after adjustment for confounders \u2013 paternal age-at-birth, smoking, body mass index (BMI) and physical activity (p-trend\u200a=\u200a0.15). Notably, a threshold was identified. Among women with Crown-Crisp&lt;6 points, the multivariable-adjusted least-squares mean RTL <em>z<\/em>-score\u200a=\u200a0.02 standard units; however, among the most phobic women (Crown-Crisp\u22656), the multivariable-adjusted least-squares mean RTL <em>z<\/em>-score\u200a=\u200a\u22120.09 standard units (mean difference\u200a=\u200a\u22120.10 standard units; p\u200a=\u200a0.02). The magnitude of this difference was comparable to that for women 6 years apart in age. Finally, effect modification by BMI, smoking and paternal age was observed: associations were stronger among highly phobic women with BMI\u226525 kg\/m<sup><font size=\"2\">2<\/font><\/sup>, without smoking history, or born to fathers aged \u226540 years.<\/p>\n<\/div>\n<div class=\"section toc-section\" id=\"section3\"><a title=\"Conclusions\/Significance\" class=\"link-target\"><\/a> <\/p>\n<h3>Conclusions\/Significance<\/h3>\n<p><a name=\"article1.front1.article-meta1.abstract1.sec3.p1\" class=\"link-target\" id=\"article1.front1.article-meta1.abstract1.sec3.p1\"><\/a><\/p>\n<p>In this large, cross-sectional study high phobic anxiety was associated with shorter telomeres. These results point toward prospective investigations relating anxiety to telomere length change.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<div tabindex=\"0\" class=\"gs_citr\">Okereke, O. I., Prescott, J., Wong, J. Y., Han, J., Rexrode, K. M., &amp; De Vivo, I. (2012). High phobic anxiety is related to lower leukocyte telomere length in women. <i>PloS one<\/i>, <i>7<\/i>(7), e40516.<\/div>\n<p><a href=\"https:\/\/doi.org\/10.1371\/journal.pone.0040516\">https:\/\/doi.org\/10.1371\/journal.pone.0040516<\/a> &nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Background Chronic psychological distress has been linked to shorter telomeres, an indication of accelerated aging. Yet, little is known about relations of anxiety to telomeres. We examined whether a typically chronic form of anxiety \u2013 phobic anxiety \u2013 is related to telomere length. Methodology\/Principal Findings Relative telomere lengths (RTLs) in peripheral blood leukocytes were measured [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"jnews-multi-image_gallery":[],"jnews_single_post":[],"jnews_primary_category":[],"jnews_social_meta":[],"jnews_override_counter":[],"footnotes":""},"categories":[28,15],"tags":[308,309],"_links":{"self":[{"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1925"}],"collection":[{"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcomments&post=1925"}],"version-history":[{"count":1,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1925\/revisions"}],"predecessor-version":[{"id":1926,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=\/wp\/v2\/posts\/1925\/revisions\/1926"}],"wp:attachment":[{"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fmedia&parent=1925"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Fcategories&post=1925"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.happyfinder.co.kr\/index.php?rest_route=%2Fwp%2Fv2%2Ftags&post=1925"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}